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Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion

✍ Scribed by Shereen Sabet; Maria-Teresa Ochoa; Peter A. Sieling; Thomas H. Rea; Robert L. Modlin


Book ID
108782004
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
679 KB
Volume
120
Category
Article
ISSN
0019-2805

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The establishment of IL-2-independent T-cell lines spontaneously derived from long-term IL-2-dependent cytotoxic T-cell lines is described. Two lines (cloned and uncloned) studied in detail have shown the following characteristics: (1) Permanent loss of IL-2 dependence. (2) Partial or complete loss