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Functional Characterization of A Cis-Acting Temperature Sensitive Mutation From A Respiratory Syncytial Virus Vaccine Candidate

โœ Scribed by Teng, Michael; Fitzhugh, David J.; Tran, Kim; Lockey, Richard F.; Collins, Peter


Book ID
122860685
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
41 KB
Volume
131
Category
Article
ISSN
1097-6825

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A cold-passaged (cp) temperature-sensitive (ts) mutant of human respiratory syncytial virus designated RSV cpts-248 was previously derived by random chemical mutagenesis of the non-ts mutant cp-RSV that possesses one or more host range mutations. We previously demonstrated in rodents and seronegativ