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Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

✍ Scribed by Slifka, Mark K.; Whitton, J. Lindsay

Book ID: 109832001
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 204 KB
Volume: 2
Category: Article
ISSN: 1529-2908
DOI: 10.1038/90650

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## Abstract Activation of mature CD8^+^ T cells requires recognition, __via__ the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteri