Functional assessment of pancreatic parenchyma after secretin administration using serial T2-weighted echo-planar magnetic resonance imaging
✍ Scribed by Takayuki Masui; Motoyuki Katayama; Shigeru Kobayashi; Tatsuhiko Ito; Hiroyuki Kabasawa; Atsushi Nozaki; Harumi Sakahara
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 242 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Signal intensity (SI) changes of pancreatic parenchyma were evaluated after intravenous administration of secretin using T2‐weighted single‐shot spin‐echo echo‐planar imaging (EPI) to assess this method as a magnetic resonance (MR) test of pancreatic exocrine function. Nine volunteers were studied with serial single‐shot EPI of the pancreas for 15 minutes after the injection of secretin or saline. The normal pattern of pancreatic SI change was demonstrated after intravenous injection of secretin, a single peak at 3–4 minutes in the head, body, and tail, followed by a gradual decrease in SI. Saline injection did not induce a significant SI change. There was no statistical difference in the peak contrast ratios (first mean, 1.21–1.25, vs. second mean, 1.18–1.22) and peak times (first mean, 3.2–3.7 minutes, vs. second mean, 3.1–3.6) in a repeat study. By evaluating the pattern of time‐response curves obtained from serial T2‐weighted EPI after secretin injection, pancreatic exocrine function may be directly assessed at the level of the head, body, and tail. J. Magn. Reson. Imaging 2001;14:450–456. © 2001 Wiley‐Liss, Inc.