Functional assessment of angiotensin II and bradykinin analogues containing the paramagnetic amino acid TOAC
✍ Scribed by Edson L. Santos; Kely de Picoli Souza; Regiane A. Sabatini; Renan P. Martin; Liliam Fernandes; Daniela T. Nardi; Luciana Malavolta; Suma I. Shimuta; Clóvis R. Nakaie; João B. Pesquero
- Book ID
- 116576220
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 312 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1567-5769
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## Abstract N‐Terminally and internally labeled analogues of the hormones angiotensin (AII, DRVYIHPF) and bradykinin (BK, RPPGFSPFR) were synthesized containing the paramagnetic amino acid 2,2,6,6‐tetramethylpiperidine‐1‐oxyl‐4‐amino‐4‐carboxylic acid (TOAC). TOAC replaced Asp^1^ (TOAC^1^‐AII) and
## Abstract L‐Phenylalanine has been treated with chlorosulfonic acid and the product was either hydrolyzed, ammonolyzed or reduced. The resulting sulfonic‐acid and aminosulfonyl derivatives have been employed for peptide synthesis with Boc‐protection of the N^α^‐position only. The reduction produc
## Abstract The synthesis of the polyhalogenated phenylalanines Phe(3′,4′,5′‐Br~3~) (**3**), Phe(3′,5′‐Br~2~‐4′‐Cl) (**4**) and DL‐Phe (2′,3′,4′,5′,6′‐Br~5~) (**9**) is described. The trihalogenated phenylalanines **3** and **4** are obtained stereospecifically from Phe(4′‐NH~2~) by electrophilic b