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Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C

✍ Scribed by Louise J. Brown; Leena Singh; Kenneth L. Sale; Bing Yu; Ronald Trent; Peter G. Fajer; Brett D. Hambly


Publisher
Springer
Year
2002
Tongue
English
Weight
195 KB
Volume
31
Category
Article
ISSN
1432-1017

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Porcine odorant binding protein (pOBP) contains a single disulphide bridge linking residues Cys63 and Cys155. In order to get information on the role played by this crosslink in determining the structural and functional properties of the protein, we substituted these two Cys residues with two Ala re