Functional and molecular organisation of an antigen-specific suppressor factor from a T-cell hybridoma
β Scribed by Taniguchi, Masaru; Takei, Izumi; Tada, Tomio
- Book ID
- 109717282
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 260 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/283227a0
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Antigen-specific T cell suppressor factor (TsF): isolation of a cDNA clone encoding for a functional polypeptide chain of phosphorylcholine-specific TsF\* A cDNA library of phosphorylcholine (PC)-specific suppressor T hybridoma, 29-C-6, was constructed. By differential colony hybridization, 68 colon
The antigen-specific T suppressor cell clone HF1 isolated from a CBA/J mouse made tolerant by low doses of bovine serum albumin has suppressive and cytolytic activity. The analysis of the latter gave the following results. Natural killer (NK)-sensitive YAC-1 (H-2a) and RBL-5 (H-2b) target cells are