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Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma

โœ Scribed by Xie, Jiayin; Zhang, Liang; Li, Mengxia; Du, Jia; Zhou, Liwei; Yang, Senlin; Zeng, Linli; Li, Zengpeng; Wang, Ge; Wang, Dong


Book ID
121565455
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
750 KB
Volume
14
Category
Article
ISSN
1471-2407

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โœ C. G. Adair; J. M. Bridges; Z. R. Desai ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 329 KB

Pharmacokinetic studies in 11 patients with multiple myeloma were undertaken on the first and last days of one course of chemotherapy. The drug was administered PO in single doses of 6-14 mg daily. Melphalan concentrations were determined by high-performance liquid chromatography. The interpatient v