Functional analysis of the human MCL-1 gene
β Scribed by C. Akgul; P. C. Turner; M. R. H. White; S. W. Edwards*
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 339 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1420-682X
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UBC11 is the Saccharomyces cerevisiae gene that is most similar in sequence to E2-C, a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe. We have disrupted the UBC11 gene and
## Abstract Hypoxiaβinducible factorβ1Ξ± (HIFβ1Ξ±) and myeloid cell leukemiaβ1 (Mclβ1) proteins have been shown to regulate apoptosis in some cell systems but have not been studied in this context in airway epithelium. Using a model of anoxia/reoxygenation (A/R), the present study employed RNA interf