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Functional analysis of the C(–188)A polymorphism of the human leptin promoter

✍ Scribed by L. Oksanen; J. J. Palvimo; O. A. Jänne; K. Kontula

Publisher
Springer
Year
1998
Tongue
English
Weight
61 KB
Volume
103
Category
Article
ISSN
0340-6717

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## Abstract Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity‐related stimuli. The leptin promoter polymorphism Lep‐2548G/A can be associated with increased leptin secretion by adipocytes and elevated cancer risk. However, molecular mechani