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Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene

✍ Scribed by Boulling, Arnaud; Le Maréchal, Cédric; Trouvé, Pascal; Raguénès, Odile; Chen, Jian-Min; Férec, Claude


Book ID
110027073
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
153 KB
Volume
15
Category
Article
ISSN
1018-4813

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## Communicated by Richard G.H. Cotton Mutations in the serine protease inhibitor Kazal type 1 gene (SPINK1) encoding pancreatic secretory trypsin inhibitor (PSTI) have recently been found to be associated with chronic pancreatitis. Nevertheless, knowledge of severe mutations is particularly scarc