Functional analysis of different LMP1 proteins isolated from Epstein–Barr virus-positive carriers
✍ Scribed by Nicole Fischer; Bernd Kopper; Norbert Graf; Jörg R Schlehofer; Friedrich A Grässer; Nikolaus Mueller-Lantzsch
- Book ID
- 117366638
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 302 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0168-1702
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## Abstract There are two types of Epstein Barr virus (EBV): EBV‐1 and EBV‐2, distinguished by genomic polymorphism in the genes encoding the nuclear antigens (EBNA‐2, ‐3A, ‐3B, ‐3C). Latent membrane protein 1 (LMP‐1) is an EBV protein with known oncogenic properties. Different variants had been de
Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gen