The stimulation or inhibition of adenylate cyclase by hormones and chemicals is mediated by the stimulatory or inhibitory guanine nucleotide-binding proteins, Gs and Gi respectively. Although the presence of these G-proteins in the epidermis has been suggested, no direct information regarding their
Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis
β Scribed by Tamura, T; Takahashi, H; Ishida-Yamamoto, A; Hashimoto, Y; Iizuka, H
- Book ID
- 119561444
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 146 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0923-1811
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Guanine nucleotide regulatory proteins (G-proteins) play an important role in the onset and progression of malignancy. We hypothesized that alterations in inhibitory G-protein (Gi) expression and/or function may contribute to cellular invasion and formation of hepatocellular carcinoma (HCC). H4IIE h