Function of lymphocyte subpopulations in chronic lymphocytic leukemia. Activity in the allogeneic and autologous mixed lymphocyte reaction

✍ Scribed by Jeffrey A. Wolos; Frederick R. Davey

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 595 KB
• Volume: 45
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19800301)45:5<893::aid-cncr2820450511>3.0.co;2-q

✦ Synopsis

Lymphocyte subpopulations from patients with chronic lymphocytic leukemia (CLL) and from normal age-matched controls were evaluated for their ability to participate in allogeneic and autologous mixed lymphocyte reactions (MLR). Unfractionated and T enriched lymphocyte populations from normal age-matched controls responded well to allogeneic stimulation. T enriched lymphocytes from patients will CLL also responded to allogeneic lymphocytes. B enriched lymphocytes from normal age-matched individuals produced a stronger stimulus in the allogeneic MLR than did unfractionated mononuclear cell populations. Unfractionated and B enriched lymphocyte subpopulations from patients with CLL were poor stimulators in the allogeneic MLR. In normal age-matched controls T enriched lymphocyte subpopulations were able to respond to autologous B enriched lymphocytes. Autologous mixed lymphocyte cultures from patients with CLL failed to demonstrate any activity.