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Function and dysfunction of presenilin in Alzheimer’s disease

✍ Scribed by Jie Shen


Book ID
121622656
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
72 KB
Volume
8
Category
Article
ISSN
1750-1326

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Presenilin mutations in Alzheimer's dise
✍ Marc Cruts; Christine Van Broeckhoven 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB 👁 2 views

The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The