The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA pro
Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice
β Scribed by T. Arai; H. Hashimoto; K. Kawai; A. Mori; Y. Ohnishi; K. Hioki; M. Ito; M. Saito; Y. Ueyama; M. Ohsugi; R. Suzuki; N. Kubota; T. Yamauchi; K. Tobe; T. Kadowaki; K. Kosaka
- Book ID
- 106300404
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 252 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0372-8722
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## Abstract ## Objective The contribution of innate immunity responsible for betaβcell destruction in fulminant type 1 diabetes (FT1D) and slowly progressive insulinβdependent diabetes mellitus (SPIDDM) is unclear. ## Research Design and Methods Isletβcell expression of Tollβlike receptors (TLRs
Humoral and cell-mediated disorders in Type 1 (insulin-dependent) diabetes suggest that an imbalance of immunoregulatory T-cell subsets exists. In 23 newly diagnosed (onset less than 3 months) and 21 long-standing Type 1 diabetic patients, T lymphocyte subsets were analyzed using monoclonal antibodi