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Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects

✍ Scribed by Roberta Borghi; Roberta Marchese; Alessandro Negro; Lucio Marinelli; Gianluigi Forloni; Damiano Zaccheo; Giovanni Abbruzzese; Massimo Tabaton

Book ID
117470816
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
123 KB
Volume
287
Category
Article
ISSN
0304-3940

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## Abstract Although alpha‐synuclein is the main constituent of Lewy bodies, cerebrospinal fluid determination on its own does not seem fundamental for the diagnosis of synucleinopathies. We evaluated whether the combination of classical biomarkers, Aβ~1–42~, total tau, phosphorylated tau, and α‐sy