Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes

The selected flavonol glycoside derived

The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells

✍ Do Thi Ha; Trinh Nam Trung; Tran Thi Phuong; Namhui Yim; Quan Cheng Chen; KiHwan 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 924 KB

Among nine flavonols (1-9) obtained from Sophorae Flos, we first isolated compounds 4, 5, 8, and 9. These isolates (1-9) were evaluated for the phosphorylation of AMPK and ACC. Administered at 10 lM, 9 possessed high potent activity. Compound 9 displayed a dose-dependent stimulation of glucose uptak