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FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs

✍ Scribed by Matthias Hofmann; Volker Brinkmann; Hans-Günter Zerwes

Book ID
116576049
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
546 KB
Volume
6
Category
Article
ISSN
1567-5769

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## Abstract Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of __Foxo1__, we generated mice that selectively lack __Foxo1__ in T cells (__Foxo1__^flox/flox^ __Lck__.__cre__^+^conditional knockout mice (cKO)). Although thymocy