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FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion

✍ Scribed by Samuel Yen; Colin Easson; Parimala Nacharaju; Michael Hutton; Shu-Hui Yen


Book ID
117111662
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
443 KB
Volume
461
Category
Article
ISSN
0014-5793

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Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), historically termed Pick's disease. Most FTDP-17 cases show neuronal and/or glial inclusions that stain positively with antibodies r