✦ LIBER ✦

Fruit and vegetable intake and esophageal cancer in a large prospective cohort study

✍ Scribed by Neal D. Freedman; Yikyung Park; Amy F. Subar; Albert R. Hollenbeck; Michael F. Leitzmann; Arthur Schatzkin; Christian C. Abnet

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 101 KB
Volume: 121
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22993

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Changing patterns of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) incidence worldwide suggest distinct etiologies. Although associations between fruit and vegetable intake and both ESCC and EAC have been found in multiple ecological and case–control studies, few prospective studies have investigated these associations. We prospectively examined these associations in 490,802 participants of the National Institutes of Health (NIH)‐AARP Diet and Health Study using Cox models adjusted for age, alcohol intake, body mass index, cigarette smoking, education, physical activity and total energy intake. We present hazard ratios and 95% confidence intervals per serving per 1,000 calories. During 2,193,751 person years of follow‐up, 103 participants were diagnosed with ESCC and 213 participants with EAC. We found a significant inverse association between total fruit and vegetable intake and ESCC risk (HR: 0.78, 95% CI: 0.67–0.91), but not EAC risk (0.98, 0.90–1.08). In models mutually adjusted for fruit and vegetable intake, the protective association with ESCC was stronger for fruits (0.73, 0.57–0.93) than for vegetables (0.84, 0.66–1.07). When we examined botanical subgroups, we observed significant protective associations for ESCC and intake of Rosacea (apples, peaches, nectarines, plums, pears and strawberries) and Rutaceae (citrus fruits). A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Fruit and vegetable intake and head and

Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study

✍ Neal D. Freedman; Yikyung Park; Amy F. Subar; Albert R. Hollenbeck; Michael F. L 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 92 KB 👁 2 views

## Abstract Squamous head and neck cancers include cancers of the oral cavity, pharynx and larynx are the sixth leading cause of cancer mortality worldwide, resulting in more than 350,000 deaths annually. Intake of fruit and vegetables may protect against head and neck cancer incidence, although fe

Vegetables and fruits consumption and ri

Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study

✍ Jessie Steevens; Leo J. Schouten; R. Alexandra Goldbohm; Piet A. van den Brandt 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 281 KB 👁 2 views

## Abstract Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EA

Fruits, vegetables and lung cancer: A po

Fruits, vegetables and lung cancer: A pooled analysis of cohort studies

✍ Stephanie A. Smith-Warner; Donna Spiegelman; Shiaw-Shyuan Yaun; Demetrius Albane 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB 👁 1 views

## Abstract Inverse associations between fruit and vegetable consumption and lung cancer risk have been consistently reported. However, identifying the specific fruits and vegetables associated with lung cancer is difficult because the food groups and foods evaluated have varied across studies. We

Intake of vegetables, fruits, carotenoid

Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study

✍ Mirjam M. Heinen; Bas A.J. Verhage; R. Alexandra Goldbohm; Piet A. van den Brand 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 172 KB 👁 2 views

## Abstract Epidemiological data investigating the relation between fruit and vegetable consumption and pancreatic cancer risk have shown inconsistent results so far. Most case‐control studies observed an inverse association with total fruit and vegetable consumption, whereas results from most coho

Bladder-cancer incidence in relation to

Bladder-cancer incidence in relation to vegetable and fruit consumption: A prospective study of atomic-bomb survivors

✍ Jun Nagano; Suminori Kono; Dale L. Preston; Hiroko Moriwaki; Gerald B. Sharp; Ko 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 70 KB 👁 2 views

We examined the relation between consumption of 22 dietary items and subsequent bladder-cancer incidence in a cohort of atomic-bomb survivors in Japan. Subjects were 38,540 people (14,873 men and 23,667 women) who responded to a mail survey carried out between 1979 and 1981 and who had no known canc

Cohort analysis of fruit and vegetable c

Cohort analysis of fruit and vegetable consumption and lung cancer mortality in European men

✍ Margje C.J.F. Jansen; H. Bas Bueno-de-Mesquita; Leena Räsänen; Flaminio Fidanza; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB 👁 1 views

Our aim was to examine the relationship between fruit and vegetable consumption and lung cancer mortality in a cohort of European males. Around 1970, dietary intake of Finnish, Italian and Dutch middle-aged men was assessed using a cross-check dietary history. Complete baseline information was avail