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Fructose-1, 6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat

✍ Scribed by Dr. L. Galzigna; M. Bianchi; V. Rizzoli; R. Scuri; P. Giannetti; A. Paesano

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 527 KB
Volume: 8
Category: Article
ISSN: 0263-6484
DOI: 10.1002/cbf.290080107

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✦ Synopsis

Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36C1-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.

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