Frontotemporal dementia is on the MAPτ

Novel biphasic effect of pyrrolidine dit

Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-κb, and MAP kinases

✍ Kwang Chul Chung; Jae Hyun Park; Chul Hoon Kim; Hyun Woo Lee; Noboru Sato; Yasuo 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB 👁 1 views

Nuclear factor B (NF-B) is a transcription factor involved in the expression of a wide range of genes, most of which code for proteins that play a role in immunity and inflammation. Pyrrolidine dithiocarbamate (PDTC) is a well-known inhibitor of NF-B. Although its mechanism of action is conferred by