Frontal sinus and skull bone defect obliteration with three synthetic bioactive materials. A comparative study
✍ Scribed by Matti J. Peltola; Kalle M. J. Aitasalo; Jouko T. K. Suonpää; Antti Yli-Urpo; Pekka J. Laippala; Ari-Pekka Forsback
- Book ID
- 102875095
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 538 KB
- Volume
- 66B
- Category
- Article
- ISSN
- 1552-4973
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✦ Synopsis
Abstract
Three synthetic bioactive materials were studied in an experimental model to compare their usability in a frontal sinus and a skull bone defect obliteration. Bioactive glass number 9 (BAG^1^), bioactive glass number 13 (BAG^2^), and hydroxyapatite (HA) granules were investigated. BAG^1^ and HA granules have been previously tested clinically. The clinical usefulness of BAG^2^ granules has not been tested. Upper bony walls of 45 Elco rabbits' frontal sinuses were drilled open from four separate holes with the use of a standard method. The skull bone defects and the sinuses in frontal bone were filled with BAG^1^ or BAG^2^ on one side, and with HA on the other side. Two parallel posterior defects were covered with a pedicled periosteum flap, and two anterior defects with a free flap. The resorption of materials, new bone, and fibrous‐tissue formation were observed with a histomorphometric method at 1, 3, and 6 months postoperatively. Scanning‐electron microscopy (SEM) and Fourier‐transform infrared spectroscopy (FTIR) were done at 6 months. In histomorphometry, the new bone formation increased with all the investigated materials throughout the study (p < 0.001), but the results showed higher new bone formation in the defects filled with BAG^1^ than in corresponding BAG^2^‐ or HA‐ filled defects. New bone formation and resorption of materials were faster in defects covered by pedicled than by free periosteum flaps (p < 0.001). Intimate contact between the used materials and new bone was confirmed by SEM. FTIR analysis of bone produced by BAG^1^ and BAG^2^ was of the same type as natural frontal bone. BAG^2^ can be manufactured in various shapes, and thus, could possibly be used in clinical conditions requiring a special anatomical implant shape. However, more research is needed regarding this property of BAG^2^. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 364–372, 2003