𝔖 Bobbio Scriptorium
✦   LIBER   ✦

From theory to therapy: Implications from an in vitro model of ramified microglia

✍ Scribed by Philip Rosenstiel; Ralph Lucius; Günther Deuschl; Jobst Sievers; Henrik Wilms

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
322 KB
Volume
54
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

Microglia are the principal immune cells in the central nervous system (CNS), characterized by a highly specific morphology and unusual antigenic phenotype. An increasing number of studies have focused on the role of microglia in the pathogenesis of neurodegenerative diseases. To elucidate the function of microglial cells under several neuropathological conditions, we have studied and established a cell culture model that allows us to cultivate microglial cells in their inactive, resting (ramified) phenotype. In the first part of this work, we describe the interaction of microglia cells with their epithelial (astrocytic) microenvironment. The second part reviews experiments with microglia cell cultures to elucidate underlying signalling pathways and summarizes recent advances of our knowledge in microglial molecular pathways that may ultimately lead to neurodegeneration. Microsc. Res. Tech. 54:18–25, 2001. © 2001 Wiley‐Liss, Inc.

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