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From Structure to Function: A New Approach to Detect Functional Similarity among Proteins Independent from Sequence and Fold Homology

✍ Scribed by Stefan Schmitt; Manfred Hendlich; Gerhard Klebe

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 199 KB
Volume: 40
Category: Article
ISSN: 0044-8249
DOI: 10.1002/1521-3773(20010903)40:17<3141::aid-anie3141>3.0.co;2-x

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✦ Synopsis

Protein function is almost invariably linked with the specific recognition of substrates or endogenous ligands in particular binding pockets; proteins of related function should, therefore, share comparable recognition pockets. On the basis of this idea a new computer method has been developed to detect functional relationships among proteins, independent of a particular sequence or fold homology, in which the functionality of the residues is translated into simple physicochemical descriptors. By this method novel ligands in drug design can be suggested.

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