From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones
✍ Scribed by Harvey Lodish; Johan Flygare; Song Chou
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 155 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.322
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✦ Synopsis
Abstract
This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU‐E progenitors; (2) the regulated expansion of the pool of earlier BFU‐E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages. © 2010 IUBMB IUBMB Life 62(7): 492–496, 2010