From Small Ideas. . . . . .come great achievements. Small has successfully completed its fifth year and continues to go from strength to strength. The growing importance of nano-and microtechnology in science has seen a tremendous increase in publication activities in this field in the past decade. Combined with the fact that the 2008 Impact Factor of Small increased to 6.5, this has led to a staggering increase in the number of submissions to the journal, which has doubled in the past two years. We have to apply rigorous selection criteria to ensure that the very best papers are accepted. I thank my Deputy Editor, Mary Farrell, who has helped me in this difficult task. Our strict peer-review process has helped us to select the top 15% of submissions, which were accepted for publication. This task would not have been possible without the help of our referees, who selflessly offer their time and expertise in the evaluation of the scientific content of the papers. I thank all of our referees for their indispensible contribution to our success. Table 1 lists our Top 50 referees, those who have evaluated the most manuscripts in the course of 2009. I would be remiss not to also thank the hard-working members of our Editorial Advisory Board for their constant support and advice.