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From sarcomere to cell: an efficient algorithm for linking mathematical models of muscle contraction

✍ Scribed by Nicolas P. Smith


Publisher
Springer
Year
2003
Tongue
English
Weight
291 KB
Volume
65
Category
Article
ISSN
1522-9602

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✦ Synopsis


S iso , T iso , E iso Cross-bridge stiffness, tension and energy at isometric equilibrium b Actin site spacing Normalized muscle spatial scale divided by the cross-bridge scale (x) ω Frequency of sinusoidal perturbation Y (ω) Complex modulus function relating stiffness to perturbation frequency ϑ Passive component of the complex modulus function θ i Characteristic time constant i of relaxation to isometric equilibrium i Magnitude of contribution to complex stiffness from characteristic relaxation rate θ i Q i Pseudo-macroscopic state i τ Time integration variable v(t) Contraction velocity a(t) Contraction acceleration r Parameter to identify the moment of the probability distribution M r i The r th moment of state i A i Area under the probability profile P i (x, t) of state i σ i Standard deviation of the probability profile P i (x, t) of state i µ i Mean of the probability profile P i (x, t) of state i γ First generic integral term used to determine M r i and temporal derivatives ϒ Second generic integral term used to determine M r i and temporal derivatives J r

The r th moment of the error function U

The matrix containing the partial derivatives used to calculate the Newton step v

The Newton step direction w

The right-hand side vector of the determination of the Newton step