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From Mechanistic Studies on Artemisinin Derivatives to New Modular Antimalarial Drugs

✍ Scribed by Robert, Anne; Dechy-Cabaret, Odile; Cazelles, Jérôme; Meunier, Bernard


Book ID
115545076
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
139 KB
Volume
35
Category
Article
ISSN
0001-4842

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The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com