From Combinatorial Chemistry to Chemical Microarray
โ Scribed by Kit S. Lam; Manat Renil
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 22 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
This article describes the exploration of synthetic methodologies on solid phase for combinatorial chemistry. Examples will cover various cyclisation strategies that include; the intramolecular Heck cyclisation leading to the formation of oxindoles, the radical cyclisation mechanism in the synthesis
## Abstract **Summary:** High throughput characterization of combinatorial libraries demands a compromise between completeness of the study and reasonable investigation time. This compromise can be found by the development of test protocols consisting of the minimal number of the most informative m