From cell biology to immunology—A short trip

✍ Scribed by Leonard A. Herzenberg

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 641 KB
• Volume: 76
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040760309

✦ Synopsis

Abstract

Immunologic memory and immunoglobulin allotype suppression are discussed as problems in Cell Biology. Memory, the ability of an animal after a first antigenic exposure to give a heightened and faster immune response upon a second exposure to the same antigen, is shown to be a property of bone marrow‐derived cell lines. Expression of this memory depends on interaction with thymus‐derived cells from either non‐immunized or immunized mice.

Chronic allotype suppression is described for the first time. It is initiated by in utero or neonatal exposure of (SJL × BALB/c)F~1~ mice, allotype a/b, to anti b antibody. Suppression lasts for long periods and continues in irradiated recipients which have received lymphoid cells from suppressed donors. Selection against b allotype producing cell precursors can explain suppression.