From Axial Chirality to Central Chiralities: Pinacol Cyclization of 2,2′-Biaryldicarbaldehyde to trans-9,10-Dihydrophenanthrene-9,10-diol

From Central to Axial to Central Chirali

From Central to Axial to Central Chirality: Enantioselective Construction of the trans-4,5,9,10-Tetrahydroxy-9,10-dihydrophenanthrene System

✍ Georgi Stavrakov; Manfred Keller; Bernhard Breit 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 278 KB 👁 2 views

## Abstract Enantioselective synthesis of the core __trans__‐4,5,9,10‐tetrahydroxy‐9,10‐dihydrophenanthrene parent system of the antibiotics benanimicin, pradimicin and FD 594 has been accomplished. The synthesis employs a chiral tether approach and makes use of efficient central to axial to centra