Friend lymphatic leukemia virus-induced autoimmune hemolytic anemia with glomerulpnephritis in the rat

✍ Scribed by Noboru Kuzumaki; Takao Kodama; Noritoshi Takeichi; Hiroshi Kobayashi

• Book ID: 102868226
• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: French
• Weight: 758 KB
• Volume: 14
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910140408

✦ Synopsis

Abstract

WKA/Mk rats injected with Friend lymphatic leukemia virus at birth developed a runt ing syndrome which was associated with a high incidence of hemolytic anemia. The anemia was characterized by the presence of incomplete anti‐erythrocyte autoantibodies detected by the direct antiglobulin test and the indirect enzyme‐augmented hemagglutination assay, and, in some cases, was followed by glomerulonephritis. This system in the rat may represent a new model of autoimmune hemolytic anemia in man.