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Friedel–Crafts reaction of indoles with N-silyl-N,O-acetal catalyzed by Cu(OTf)2 in the presence of TMSCl leading to indolyl primary amines

✍ Scribed by Norio Sakai; Toshihiro Hamajima; Takeo Konakahara


Book ID
104251339
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
84 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


A catalytic amount of copper(II) trifluoromethanesulfonate (Cu(OTf) 2 ) in the presence of trimethylchlorosilane (TMSCl) effectively promoted the aminomethylation of indoles bearing a variety of functional groups with a N-silyl-N,O-acetal in good to excellent yields.


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