Friedel–Crafts reaction of indoles with N-silyl-N,O-acetal catalyzed by Cu(OTf)2 in the presence of TMSCl leading to indolyl primary amines

✍ Scribed by Norio Sakai; Toshihiro Hamajima; Takeo Konakahara

• Book ID: 104251339
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 84 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00921-8

✦ Synopsis

A catalytic amount of copper(II) trifluoromethanesulfonate (Cu(OTf) 2 ) in the presence of trimethylchlorosilane (TMSCl) effectively promoted the aminomethylation of indoles bearing a variety of functional groups with a N-silyl-N,O-acetal in good to excellent yields.