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Friedel–Crafts acylation of indoles in acidic imidazolium chloroaluminate ionic liquid at room temperature

✍ Scribed by Kap-Sun Yeung; Michelle E Farkas; Zhilei Qiu; Zhong Yang


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
117 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


A practical and convenient protocol has been developed for the acidic 1-ethyl-3-methylimidazolium chloroaluminate ionic liquid (generated from 1-ethyl-3-methylimidazolium chloride (EmimCl) and aluminium chloride (X(AlCl 3 ), mole fraction X=0.67-0.75) promoted Friedel-Crafts acylation of indoles at room temperature. The simple experimental procedure provides 3-substituted indoles in good to high yields with less electron rich indole ring systems.


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