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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

✍ Scribed by Bastian, Boris C.; Van Raamsdonk, Catherine D.; Bezrookove, Vladimir; Green, Gary; Bauer, Jürgen; Gaugler, Lona; O’Brien, Joan M.; Simpson, Elizabeth M.; Barsh, Gregory S.


Book ID
109897901
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
618 KB
Volume
457
Category
Article
ISSN
0028-0836

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## Abstract Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46–64% of somatic mutations in the D‐loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far