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Frequent occurrence of familial aggregations of high lipoprotein(a) levels associated with small apolipoprotein(a) isoforms

✍ Scribed by Hisako Yanagi; Akiko Nakagawa; Shuichi Kikuchi; Takako Tanaka; Shigeru Tsuchiya; Hideo Hamaguchi

Book ID: 104769040
Publisher: Springer
Year: 1993
Tongue: English
Weight: 623 KB
Volume: 92
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00420936

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✦ Synopsis

School-age children with high lipoprotein (a) [Lp(a)] levels were screened and family studies were conducted to examine the relationship between high Lp(a) levels and apolipoprotein(a) [apo(a)] isoforms in families. All the probands from 17 families had one of the A2 to A12 apo(a) isoforms, which are the smaller apo(a) isoforms of the 25 different isoforms thus far detected. The ratio of subjects with high plasma Lp(a) levels was 0.47 among the first-degree relatives. All 15 relatives with high plasma Lp(a) levels shared one of the small apo(a) isoforms with the proband in each family, while 16 of 17 relatives with normal Lp(a) levels did not. These data indicate the frequent occurrence of familial aggregations of high Lp(a) levels associated with one of the small apo(a) isoforms.

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