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Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma

✍ Scribed by Karoliina Stefanius; Laura Ylitalo; Anne Tuomisto; Rami Kuivila; Tiina Kantola; Päivi Sirniö; Tuomo J Karttunen; Markus J Mäkinen

Book ID
110092813
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
402 KB
Volume
58
Category
Article
ISSN
0309-0167

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## Abstract Mutational analysis of __KRAS__ codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti‐EGFR therapies. However, even among patients whose tumors are wildtype for __KRAS__ codons 12 and 13, only a subse