Mutations of the tumor-suppressor gene p53 are common in epithelial tumors. Clonal mutations of p53 have been found in cervical and vulvar carcinomas negative for human papillomavirus (HPV), though at least in cervical cancer HPV infection and p53 mutations are not mutually exclusive. We have previo
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
β Scribed by Petri, Bart-Jeroen; Speel, Ernst-Jan M; Korpershoek, Esther; Claessen, Sandra M H; van Nederveen, Francien H; Giesen, Vivian; Dannenberg, Hilde; van der Harst, Erwin; Dinjens, Winand N M; de Krijger, Ronald R
- Book ID
- 109889694
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 242 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0893-3952
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We have analyzed soft-tissue sarcomas (STS) molecularly for mutations in the tumor-suppressor gene p53 and immunohistochemically for expression of p53 and mdm2 proteins. In this study, tumor samples from 3 groups of soft-tissue sarcomas, i.e., fibrosarcomas, myogenic sarcomas and malignant neural tu
Point mutations of the Ki-ras andp53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropy1)amine (BHP) were investigated by polymerase chain reaction-single-strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues. Male Wistar rats 6 wk old