A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epithelial
Frequent ki-ras mutations in gastric tumors of the MSI phenotype
โ Scribed by Caroline Brennetot; Alex Duval; Richard Hamelin; Mafalda Pinto; Carla Oliveira; Raquel Seruca; Simo Schwartz Jr
- Book ID
- 119241028
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 72 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0016-5085
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Point mutations of the Ki-ras andp53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropy1)amine (BHP) were investigated by polymerase chain reaction-single-strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues. Male Wistar rats 6 wk old