Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine-associated polio cases
✍ Scribed by Galina Y. Lipskaya; A. R. Muzychenko; Olga K. Kutitova; Svetlana V. Maslova; M. Equestre; S. G. Drozdov; R. Perez Bercoff; Professor V. I. Agol
- Book ID
- 102909078
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 709 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Five representatives from a collection of 21 Sabin type 2‐like poliovirus strains isolated from paralytic poliomyelitis cases in two regions of the USSR have been subjected t o limited nucleotide sequencing. All proved to be intertypic recombinants having the genes encoding capsid proteins of Sabin 2 origin and a 3'‐end portion of the genome derived from either type 1 (3 isolates) or type 3 (2 isolates) Sabin strains. The crossover points in all the 5 genomes have been mapped to different loci of the P3 region. At least 6 additional isolates from the same collection (and 2 isolates from healthy contacts), appeared to have a type 2/type 1 recombinant genome, as judged by oligonucleotide mapping. The biological significance of frequent occurrence of recombinants among field isolates of vaccine‐related strains is discussed.