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Frequent hypermethylation of the DNA repair geneMGMTin long-term survivors of glioblastoma multiforme

✍ Scribed by Ramon Martinez; Gabriele Schackert; Ricard Yaya-Tur; Iñigo Rojas-Marcos; James G. Herman; Manel Esteller


Publisher
Springer US
Year
2006
Tongue
English
Weight
134 KB
Volume
83
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND The 5‐year survival rate for intracranial glioblastoma multiforme (GBM) has remained at 4–5% for the last 30 years, in spite of multiple randomized prospective trials. The authors hypothesized, based on the literature, that even this remarkably poor survival rate is an ov