Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s
โฆ LIBER โฆ
Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact
โ Scribed by Wang, Liang; Darling, John; Zhang, Jin-San; Qian, Chi-Ping; Hartmann, Lynn; Conover, Cheryl; Jenkins, Robert; Smith, David I
- Book ID
- 110061135
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 371 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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The recently identified FHIT gene encompasses the FRA3B region and the breakpoint of a constitutive t(3;8) occurring in a family with hereditary renal cell cancer. Occurrence of aberrant transcripts in different types of tumours has led to the suggestion that FHIT might play a critical role in the d