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Frequent EGFR mutations in nonsmall cell lung cancer presenting with miliary intrapulmonary carcinomatosis

✍ Scribed by Wu, S.-G.; Hu, F.-C.; Chang, Y.-L.; Lee, Y.-C.; Yu, C.-J.; Chang, Y.-C.; Wu, J.-Y.; Shih, J.-Y.; Yang, P.-C.

Book ID
111954475
Publisher
European Respiratory Society
Year
2012
Tongue
English
Weight
505 KB
Volume
41
Category
Article
ISSN
0903-1936

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (__EGFR__) are present in ∼10% of nonsmall cell lung cancers, and higher in never‐smokers, women, and Asians. Small in‐frame deletions in exon 19 (∼45%) and L858R mutation in exon 21 (∼40%) predict response to tre