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Frequent anti-V-region immune response to mouse B72.3 monoclonal antibody

✍ Scribed by M. B. Khazaeli; Mansoor N. Saleh; Tiepu Liu; Paul M. Kaladas; Steve C. Gilman; Albert F. LoBuglio


Publisher
Springer
Year
1992
Tongue
English
Weight
693 KB
Volume
12
Category
Article
ISSN
0271-9142

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The administration of xenogenic monoclonal antibodies (MAbs) leads in many cases to a host immune response represented by the generation of antibodies that can be directed against allotypic, isotypic, and idiotypic determinants present on the xenogeneic MAb. Anti-idiotypic antibodies (Ab2s) can be d