Frequent Alterations of Evolutionarily Conserved Regions of Chromosome 1 in Human Malignant Melanoma
โ Scribed by Ji Zhang; Arthur A Glatfelter; Raymond Taetle; Jeffrey M Trent
- Book ID
- 114136854
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 317 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Ras signaling is important for the intracellular transduction of mitogenic stimuli from activated growth factor receptors. We have investigated 37 sporadic malignant melanomas (15 primary cutaneous melanomas and 22 melanoma metastases) and 6 melanoma cell lines for mutations in the 3 Ra
Chromosome 1 abnormalities are the most commonly detected aberrations in many cancers including malignant melanomas. Specific breakpoints are reported for malignant melanomas throughout the chromosome but especially at 1p36 and at several sites throughout 1p22-q21. In addition, partial deletions and