Frequent activation of the β-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instability

The significance of microsatellite insta

The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with nonfamilial colorectal carcinoma

✍ Shigehiko Masubuchi; Fumio Konishi; Kazutomo Togashi; Tomomi Okamoto; Shingo Sen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB 👁 2 views

## BACKGROUND. Patients with metachronous multiple colorectal carcinomas have been reported to have a higher frequency of a family history of colorectal carcinoma, associated colorectal adenomas, and extracolonic malignancies. These clinicopathologic factors also are considered to be related to th