Frequent activation of mammalian target of rapamycin in primary lung adenocarcinoma and preinvasive lesion
β Scribed by Younghye Kim; Hoiseon Jeong; Aeree Kim; Han Kyeom Kim; Bong Kyung Shin
- Book ID
- 118078465
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2011
- Tongue
- English
- Weight
- 556 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1755-9294
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## Abstract **BACKGROUND:** Aberrant signaling cascades emanating from epidermal growth factor receptor (EGFR) are involved in the complex network of oncogenic signaling in lung carcinomas. One representative cascade is the phosphatidylinositol 3βkinase/Akt/mammalian target of rapamycin (mTOR) path