## Abstract Methylationβassociated inactivation of __RASSF1__, a putative tumor suppressor identified at 3p21.3, is reported in several cancers. We examined __RASSF1__ in nonβsmall lung cancer (NSCLC) to search for clinical implications. RTβPCR analysis showed no expression of __RASSF1A__ in 12 of
Frequent 3p21 allelic loss and methylation-associated RASSF1A inactivation in non-small cell lung cancer and its clinical implication
β Scribed by Hong Zhu; Maria P. Wong
- Book ID
- 107531445
- Publisher
- Wuhan University
- Year
- 2009
- Tongue
- English
- Weight
- 425 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1007-1202
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We extensively allelotyped a panel of 71 microdissected primary surgically resected non small cell lung cancer (NSCLC) tumors to identify chromosomal regions that are likely to contain tumor suppressor genes (TSGs) or associated with clinicopathologic and prognostic effects. Loss of het
To study the involvement of DNA mismatch repair genes in non-small cell lung cancer, matched normal and tumoral DNA samples from 31 patients were analyzed for both LOH and microsatellite instability with 34 markers at or linked to hMLH1 (3p21), hMSH2 (2p16), hMSH3 (5q11-q13), hMSH6 (2p16), hPMS1 (2q